PIK-293 is a cell-permeable, selective inhibitor of the phosphatidylinositol 3-kinase (PI3K) catalytic subunit p110δ (IC50s = 100, 25, 10, and 0.24 μM for p110 subunit isoforms α, β, γ, and δ, respectively).
Uses
PIK-293 is a phosphoinositide 3-kinase delta (PI3Kδ) inhibitor and the parent compound of PIK-294 (P437705). Inhibition of PI3K’s shows to be a promising approach for cancer therapy.
[1] ZACHARY A KNIGHT. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling.[J]. Cell, 2006, 125 4: 733-747. DOI: 10.1016/j.cell.2006.03.035
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