5-Acetaminonaphthalene-1-sulfonyl chloride can be used as a pharmaceutical synthesis intermediate and an organic synthesis intermediate, mainly in laboratory research and development processes and chemical and pharmaceutical synthesis processes.
Chlorosulfonic acid 3 mL (45 mmol) was added to sodium 5-(acetylamino)-1-naphthalenesulfonate (0.55 g, 2 mmol) and the reaction was stirred at room temperature for 3 h. The reaction was slowly added dropwise to 40 mL of ice water with stirring, the precipitate was filtered and dried to give 5-acetamidonaphthalene-1-sulfonyl chloride as a purple solid.
