Isoquinolin-6-ol

52986-70-6

7651-82-3

(c) 6-Methoxyisoquinoline (16 g, 0.1 mol) was mixed with 48% aqueous hydrobromic acid (600 mL) and heated to reflux for 6 hours. After completion of the reaction, the mixture was concentrated to dryness under reduced pressure. The residue was dissolved in water (H2O) and the pH was adjusted to alkaline with solid sodium carbonate (Na2CO3). The precipitated solid product was collected by filtration and recrystallized with isopropanol to give the final 6-hydroxyisoquinoline (12 g, 82% yield) with a melting point of 205°C. Literature reports a melting point of 218°-220°C (Lit.* 220°C).