基本属性 生物活性靶点体外研究体内研究 用途与合成方法 羟基伊曲康唑(伊曲康唑代谢物) 价格(试剂级) 供应商 供应信息 相关产品
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羟基伊曲康唑(伊曲康唑代谢物)

羟基伊曲康唑(伊曲康唑代谢物)

英文名称:HYDROXY ITRACONAZOLE
CAS号:112559-91-8
分子式:C35H38Cl2N8O5
分子量:721.63
EINECS号:
Mol文件:112559-91-8.mol
羟基伊曲康唑(伊曲康唑代谢物) 结构式

羟基伊曲康唑(伊曲康唑代谢物) 性质

熔点 76-78°C
沸点 884.7±75.0 °C(Predicted)
密度 1.44±0.1 g/cm3(Predicted)
储存条件 -20°C Freezer
溶解度 可溶于氯仿(少许)、乙酸乙酯(少许)、甲醇(少许)
形态 固体
酸度系数(pKa) 14.72±0.20(Predicted)
颜色 白色至浅棕色

羟基伊曲康唑(伊曲康唑代谢物) 用途与合成方法

Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole; R-63373) 是 Itraconazole (ITZ) 的活性代谢物,Itraconazole 是一种三唑类抗真菌剂。

Antifungal

Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole; R-63373) is an active metabolite of Itraconazole (ITZ). Although Hydroxy Itraconazole is also reported to have antifungal activity in vitro, its pharmacokinetics in humans has been studied less than that of ITZ. ITZ and Hydroxy Itraconazole have a triazole ring and inhibit CYP3A. Their half-lives can be extended by 26-60% with repeated administration compared to single administration.

The plasma concentration of Hydroxy Itraconazole is weakly dependent on the dose of ITZ, most likely because the process that forms Hydroxy Itraconazole is saturated. Serum albumin and GFR may alter the pharmacokinetics of ITZ and Hydroxy Itraconazole. Antifungal activity should be discussed while taking into account not only the plasma concentration of ITZ but also that of Hydroxy Itraconazole. However, the pharmacokinetics of Hydroxy Itraconazole is similar to that of ITZ in immunocompromised patients taking an oral solution of ITZ. Since the plasma concentrations of ITZ and Hydroxy Itraconazole are closely correlated, determining the plasma concentration of either should be sufficient from a clinical point of view.

羟基伊曲康唑(伊曲康唑代谢物) 价格(试剂级)

更新日期 产品编号 产品名称 CAS号 包装 价格
2024-11-08 HY-12772 羟基伊曲康唑(伊曲康唑代谢物) 112559-91-8 1mg 1900
2024-08-19 HY-12772 羟基伊曲康唑(伊曲康唑代谢物) 112559-91-8 5mg 7500

羟基伊曲康唑(伊曲康唑代谢物)供应商 更多

ChemeGen 中国
现货
联系电话: 18818260767
产品介绍:
英文名称:Hydroxy Itraconazole
CAS:112559-91-8
纯度:98%
包装信息:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
备注:品牌:ChemeGen
库存量:10g
现货日期:2024/11/15 18:20:31
北京百灵威科技有限公司
联系电话:010-82848833 400-666-7788
产品介绍:
中文名称:羟基伊曲康唑
英文名称:Hydroxy Itraconazole
CAS:112559-91-8
包装信息:10Mg,1Mg
备注:化学试剂、精细化学品、医药中间体、材料中间体
深圳振强生物技术有限公司
联系电话:0755-0755-66853366 13670046396
产品介绍:
中文名称:羟基伊曲康唑
英文名称:Itraconazole 2-Hydroxy Metabolite
CAS:112559-91-8
纯度:95% HPLC
包装信息:10mg;25mg;50mg;100mg
备注:品牌:QCS;货号:RM-I032608;可提供COA、氢谱、质谱、液相
大道生物科技(绍兴)有限公司
联系电话:0575-18780151478 18582380095
产品介绍:
中文名称:羟基伊曲康唑
英文名称:Hydroxy Itraconazole
CAS:112559-91-8
纯度:98% HPLC
包装信息:5mg 20mg 50mg 100mg 200mg 1g
上海源叶生物科技有限公司
联系电话:021-61312847; 18021002903
产品介绍:
英文名称:HYDROXY ITRACONAZOLE
CAS:112559-91-8
纯度:98%
包装信息:1mg;5mg
备注:生化试剂

最新发布供应信息

112559-91-8Hydroxy Itraconazole
上海嘉定区澄浏公路52号 2024-11-22
伊曲康唑杂质 1
湖北摩科化学有限公司 2024-11-22

"羟基伊曲康唑(伊曲康唑代谢物)"相关产品信息