IBERIOTOXIN毒素肽
IBERIOTOXIN毒素肽 用途与合成方法
Kd: 1 nM (Ca 2+ -activated K + channel)
Iberiotoxin reversibly blocks Ca2+-activated K+ channel in excised membrane patches from bovine aortic smooth muscle. Iberiotoxin acts exclusively at the outer face of the channel and functions with IC
50
values of about 250 pM. Iberiotoxin is a partial inhibitor of
125
I-charybdotoxin binding in bovine aortic sarcolemmal membrane vesicles (Ki of 2
50
pM). Iberiotoxin functions as a noncompetitive inhibitor of charybdotoxin binding.
Iberiotoxin treatment affects rat mesenchymal stem cells (rMSCs) migration in the absence of platelet lysate (PL) by inducing a decrease in cell migration suggesting that BK channels regulate rMSCs migration in basal conditions. 10 nM of Iberiotoxin abolishes the PL-induced migration effect on MSCs.
Male Wistar rats (6-7 weeks old) with chronic heart failure (CHF), Iberiotoxin (0.125 nmol/nl, 1.25 nmol/nl and 12.5 nmol/nl) is infused into paraventricular hypothalamic nucleus (PVN) by osmotic minipumps. After perfusion of Iberiotoxin by microinjection of rAAV2-KCNMB4 shRNA virus, right ventricular weight/body weight and lung weight/body weight ratio as well as left ventricular end-diastolic diameter are increased and left ventricular ejection fraction is decreased.
安全信息
| 危险品标志 | T+ |
|---|---|
| 危险类别码 | 26/27/28 |
| 安全说明 | 28-36/37-45 |
| 危险品运输编号 | UN 3462 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS号 | NH6107500 |
| F | 3-10 |
IBERIOTOXIN毒素肽 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-01-25 | HY-P0190 | IBERIOTOXIN毒素肽 | 129203-60-7 | 100μg | 3800 |
