The general procedure for the synthesis of 3-amino-5-chlorobenzonitrile from 3-chloro-5-nitrobenzonitrile was as follows: 3-chloro-5-nitrobenzonitrile was dissolved in DMF at room temperature, and 6 equivalents of SnCl2-2H2O was added, and the reaction was carried out overnight for reduction. After completion of the reaction, the target product was purified by silica gel column chromatography in 40% yield. LCMS analysis of the product (Condition A) showed a retention time of 1.61 min and a molecular ion peak [M+H]+ of 153.1.1 The 1H NMR (500 MHz, CDCl3) data were as follows: δ 6.97 (s, 1H), 6.84 (t, J = 2.0 Hz, 1H), 6.77 (s, 1H).
