Cyclo(Arg-Gly-Asp-D-Phe-Val)

Product NameCyclo(Arg-Gly-Asp-D-Phe-Val)
CAS137813-35-5
MFC26H38N8O7
MW574.63
EINECS
MOL File137813-35-5.mol

Chemical Properties

Density	1.45±0.1 g/cm3(Predicted)
storage temp.	−20°C
solubility	1 N acetic acid: 5mg/mL
pka	4.01±0.10(Predicted)
form	White solid
color	white

Safety Information

WGK Germany	3
Storage Class	11 - Combustible Solids

MSDS

Provider	Language
SigmaAldrich	English

Usage And Synthesis

Uses

Cyclo(Arg-Gly-Asp-D-Phe-Val) (Cyclo(RGDfV)) is an integrin αvβ3 inhibitor. Cyclo(Arg-Gly-Asp-D-Phe-Val) has antitumor activity. Cyclo(Arg-Gly-Asp-D-Phe-Val) can be used for the research of acute myeloid leukemia[1].

General Description

Potent inhibitor of cell adhesion. Inhibits tumor cell adhesion to laminin and vitronectin substrates. In vivo investigations in rats showed it to be useful in the amelioration of ischemic acute renal failure in rats. Also inhibits tubular obstruction by preventing cell-cell adhesion. Inhibits the redistribution of c-Src into focal adhesions, thereby leading to impaired MAP Kinase activation.

Biochem/physiol Actions

Primary Targetinhibits tumor cell adhesion to laminin and vitronectin substrates

References

[1] Shen ZH, et al. Targeting of the leukemia microenvironment by c(RGDfV) overcomes the resistance to chemotherapy in acute myeloid leukemia in biomimetic polystyrene scaffolds. Oncol Lett. 2016 Nov;12(5):3278-3284. DOI:10.3892/ol.2016.5042