CYCLO(-ARG-ALA-ASP-D-PHE-VAL) are formed by the cyclization of linear precursor peptides. C(RADfV), short for CYCLO(-ARG-ALA-ASP-D-PHE-VAL), is a cyclic polypeptide. C(RADfV) can be used to prepare and apply anti-angiogenic and immunotherapeutic drugs.