Indolo[2,3-a]quinolizine-2-acetic acid, 3-ethyl-1,2,3,4,6,7,12,12b-octahydro-8-(methoxy-d3)-α-(methoxymethylene)-, methyl ester, (αE,2S,3S,12bS)-

Mitragynine-d₃ is an analytical reference material intended for use as an internal standard for the quantification of mitragynine by GC- or LC-MS. Mitragynine is categorized as an opioid.^1,2 Mitragynine and its derivatives have been identified in products sold as incense.³ This product is intended for research and forensic applications.

1. Matsumoto, K., Mizowaki, M., Suchitra, T., et al. Central antinociceptive effects of mitragynine in mice: Contribution of descending noradrenergic and serotonergic systems Eur. J. Pharmacol. 317(1),75-81(1996).
2. Takayama, H., Ishikawa, H., Kurihara, M., et al. Studies on the synthesis and opioid agonistic activities of mitragynine-related indole alkaloids: Discovery of opioid agonists structurally different from other opioid ligands J. Med. Chem. 45(9),1949-1956(2002).
3. Kikura-Hanajiri, R., Uchiyama, N., and Goda, Y. Survey of current trends in the abuse of psychotropic substances and plants in Japan Leg. Med. (Tokyo) 13(3),109-115(2011).