氨氟沙星
氨氟沙星 性质
熔点 | 300 °C (decomp) |
---|---|
沸点 | 532.5±60.0 °C(Predicted) |
密度 | 1.44±0.1 g/cm3(Predicted) |
储存条件 | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
溶解度 | 溶于二甲基亚砜 |
形态 | 固体 |
酸度系数(pKa) | 6.17±0.41(Predicted) |
颜色 | 白色至浅黄色 |
氨氟沙星 用途与合成方法
Antibacterial
Amifloxacin (WIN 49375) is active in vitro against Pseudomonas aeruginosa isolates and shows moderate activity against Staphylococcus aureus , with MICs of less than or equal to 2 μg/mL.
Amifloxacin (WIN 49375) is highly active by the oral route, with 50% effective doses within two- to threefold of those obtained with parenteral medication. The effectiveness of Amifloxacin with various routes of medication is demonstrated with these experimental infections. When mice infected intraperitoneally with E. coli Vogel are medicated at 0.5-h postinfection subcutaneously, intravenously, or orally the ED 50 s for Amifloxacin are 0.6, 0.8, and 1.0 mg/kg, respectively. Blood radioactivity peaks at 0.5 h after oral administration of [ 14 C]Amifloxacin mesylate to rats at 20 mg/kg and is equivalent to 7.1±0.26 μg of Amifloxacin per mL. From 0.75 to 4 h, blood radioactivity decreases rapidly from 7.0±0.25 μg/mL to 1.2±0.12 μg/mL. Between 8 and 48 h the rate of decline in blood radioactivity slows and is more complex. At 48 h, the blood radioactivity is equivalent to 0.14±0.02 μg/mL. Blood levels of radioactivity after i.v. administration of [ 14 C]Amifloxacin mesylate to rats at 20 mg/kg decrease from 29.1±0.85 μg/mL at 1.0 min to 14.4±0.52 μg/mL at 10 min. From 0.25 to 4 h blood radioactivity decreases from 13.0±0.42 μg/mL to 0.97±0.09 μg/mL in a log-linear manner. The rate of elimination from 4 to 24 h is slower and more complex. At 24 h, blood radioactivity is equivalent to 0.12±0.01 ug/mL.
氨氟沙星 价格(试剂级)
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2025-02-08 | HY-U00221 | 氨氟沙星 | 86393-37-5 | 1mg | 1500 |
2025-02-08 | HY-U00221 | 氨氟沙星 | 86393-37-5 | 5mg | 3750 |