Bendogen,Lagap
Pharmaceuticals SA
A mixture of 2-bromobenzylamine (12.5 g) and S-methylthiouronium sulfate
(10 g) in water (20 ml) was heated for 1.5 hours on a steam bath in a hood,
during which methylmercaptan escaped (as evidenced by a foul odour). The
reaction mixture was then cooled and diluted with ethanol (100 ml). A
colourless solid of 2-bromobenzylguanidine sulfate was separeted, and washed
with ethanol. This solid melted at 230-232°C; it was recrystallized from water
and then melted at 247-248°C. By action of a basic agent the salt obtained
may be converted into free base.
Poison by subcutaneous andintraperitoneal routes. Moderately toxic by ingestion.When heated to decomposition it emits toxic fumes ofSOx and NOx.
Poison by intraperitoneal,subcutaneous, and intravenous routes. Moderately toxicby ingestion. When heated todecomposition it emits toxic fumes of NOx and SOx.
