(±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride

ICI 118551 is a potent, selective antagonist of the β₂-adrenergic receptor (K_i = 0.7 nM for the β₂receptor, compared with 49.5 and 611 nM for β₁ and β₃ receptors, respectively). It is active in vivo and is often used to evaluate the actions of adrenergic receptor agonists.

The (R,R)-enantiomer of ICI 118551 as highly selective β2-adrenoceptor antagonist. The S,S-enantiomer is the most potent.

ICI 118,551 hydrochloride has been used:

• to block β-adrenergic signaling in various experiments
• to counteract degradation by endogenous T-lymphocyte monoamine oxidases
• to determine the specific receptor subtype necessary for isoproterenol to induce up-regulation of gene transcripts

ICI 118,551 has been used to treat vasomotor migraines and somatic troubles related to anxiety state.

Store at RT