2,2,2-Trifluoroethylamine

2,2,2-Trifluoroethylamine can be prepared by the following steps: In a glove box, ruthenium catalyst (5 mol%, 15.2 mg, 0.025 mmol), trifluoromethylformamide (0.50 mmol, 1 equiv), and pinacolborane (2.0 mmol, 4 equiv) are added to a 25 mL Schlenk flask equipped with a magnetic stir bar. The resulting reaction mixture is stirred in an oil bath at 80 °C for 24 h. The reaction progress is monitored by TLC. After the reaction is completed, the reactants are separated by column chromatography to obtain the final product.

Figure 2. Synthetic route of 2,2,2-trifluoroethylamine.

clear colorless liquid

2,2,2-Trifluoroethanamine is a reagent used in chemical synthesis.

2,2,2-Trifluoroethylamine was used in the determination of ibuprofen (2-(p-isobutylphenyl)propionic acid), a non-steroid anti-inflammatory drug (NSAID) residue in surface and wastewater samples.

Canadian Journal of Chemistry, 32, p. 639, 1954 DOI: 10.1139/v54-083

2,2,2-Trifluoroethylamine, a volatile organic compound, was tested using corona discharge ion mobility spectrometry with orthogonal acceleration time of flight mass spectrometry (CD IMS-oaTOF).

Low toxicity by inhalation.Corrosive. Highly flammable liquid. When heated todecomposition it emits very toxic fumes of F and NOx.