焦脱镁叶绿酸Α甲酯
焦脱镁叶绿酸Α甲酯 性质
| 沸点 | 937.4±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.219±0.06 g/cm3(Predicted) |
| 储存条件 | −20°C |
| 溶解度 | 氯仿（微溶）、甲醇（微溶、加热） |
| 形态 | 固体 |
| 颜色 | 黑色 |
| 稳定性 | 感光 |
| InChIKey | RYLBYBPLWNFWPG-CMMLGHQLSA-N |
| SMILES | CCc1c(C)c2cc3[nH]c(cc4nc([C@@H](CCC(=O)OC)[C@@H]4C)c5CC(=O)c6c(C)c(cc1n2)[nH]c56)c(C)c3C=C |
焦脱镁叶绿酸Α甲酯 用途与合成方法
Pyropheophorbide-a methyl ester (2 μM; 12 h) inhibits the cell cycle progression from the G0/G1-phases and induces apoptosis at the light dosage of 55.6 kJ/m
2
in PC-3M cells.
Pyropheophorbide-a methyl ester (0.2-15 μM; 20 h) has no significant dark cytotoxicity in NCI-h446 cells.
Pyropheophorbide-a methyl ester (0.1-15 μM; 20 h) mediates a dose-dependent photocytotoxicity in the NCI-h446 cells.
Pyropheophorbide-a methyl ester (2-4 μM; 0-24 h) induces apoptosis of NCI-h446 cells in a time-dependent manner.
Pyropheophorbide-a methyl ester (0.5-4 μM; 0-20 h) shows a photocytotoxicity in PC-3M cells.
Apoptosis Analysis
| Cell Line: | PC-3M cells |
| Concentration: | 2 μM |
| Incubation Time: | 12 h |
| Result: | Apoptosis rate was about 0.27%, 6.15%, 20.49%, 50.76%, 65.39%, 64.92%, and 64.37% at 1, 3, 6, 12, 18, and 24 h posttreatment, respectively under the conditions of LC 75 (2 μM+55.6 kJ/m 2 ). |
Pyropheophorbide-a methyl ester (15 mg/kg; tail vein and topical injection) inhibits the growth of PC-3M tumors in mice.
| Animal Model: | Male BALB/c nude mice (6-8 weeks, 16-20 g) bearing PC-3M tumor |
| Dosage: | 15 mg/kg |
| Administration: | Tail vein injection and topical injection |
| Result: | The tumor volume and the weight inhibition rate were 46.78%, 41.84% in tail vein injection group and 78.66%, 72.07% in topical injection group, respectively. |
焦脱镁叶绿酸Α甲酯 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025-12-22 | HY-137473 | 焦脱镁叶绿酸Α甲酯 | 6453-67-4 | 1 mg | 400 |
| 2025-12-22 | HY-137473 | 焦脱镁叶绿酸Α甲酯 | 6453-67-4 | 5 mg | 900 |
