Ro 90-7501 exhibits antibacterial activity. In addition, it also promote both toll-like receptor 3 (TLR3) and RIG-I-like receptor (RLR) ligand-induced IFN-β gene expression and antiviral response.
ChEBI: 2-[2-(4-aminophenyl)-3H-benzimidazol-5-yl]-3H-benzimidazol-5-amine is a member of benzimidazoles.
Inhibitor of amyloid β 42 (A β 42) fibril assembly; reduces A β 42-induced toxicity (EC 50 = 2 μ M).
Ro 90-7501 (5 μg/g; intraperitoneal injection; daily; for 21 days; female BALB/c nude mice) treatment significantly delays tumor growth and significantly decreases tumor volume[1].
| Animal Model: | Female BALB/c nude mice (8-week-old) with HeLa cells under irradiation[1] |
| Dosage: | 5 μg/g |
| Administration: | Intraperitoneal injection; daily; for 21 days |
| Result: | Tumor growth was significantly delayed in the combination group. Tumor volume was also significantly decreased in the irradiation group.
|
Amyloid β42; ATM; Protein phosphatase 5; Apoptosis
