PAR4 (1-6) (mouse) (trifluoroacetate salt)

PAR4 (1-6) is a synthetic peptide agonist of proteinase-activated receptor 4 (PAR4; EC50 = 30 μM in Xenopus oocytes expressing human PAR4 receptors) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of mouse PAR4 and residues 60-65 of the full-length sequence.1 It induces calcium release in wild-type and PAR3-/- mouse platelets and in human platelets but has no activity in Xenopus oocytes expressing human PAR1. PAR4 (1-6) also triggers [3H]inositol phosphate release from KOLF cells expressing human PAR4.2WARNING This product is not for human or veterinary use.

[1] MARK L. KAHN. A dual thrombin receptor system for platelet activation[J]. Nature, 1998, 394 6694: 690-694. DOI: 10.1038/29325
[2] T R FARUQI. Structure-function analysis of protease-activated receptor 4 tethered ligand peptides. Determinants of specificity and utility in assays of receptor function.[J]. The Journal of Biological Chemistry, 2000, 275 26: 19728-19734. DOI: 10.1074/jbc.m909960199