(Ala1)-PAR4 (1-6) (mouse) (trifluoroacetate salt)

(Ala1)-PAR4 (1-6) is a synthetic peptide agonist of proteinase-activated receptor 4 (PAR4) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of mouse PAR4 and residues 60-65 of the full-length sequence with an alanine residue substituted for glycine at position 1/60.1 It is 10-fold more potent than PAR4 (1-6) (Item No. 27131), triggering [3H]inositol phosphate release from KOLF cells expressing human PAR4 at levels comparable to 30 nM thrombin (Item No. 13188) when used at a concentration of 500 μM. (Ala1)-PAR4 (1-6) induces aggregation of human platelets.2WARNING This product is not for human or veterinary use.

[1] T R FARUQI. Structure-function analysis of protease-activated receptor 4 tethered ligand peptides. Determinants of specificity and utility in assays of receptor function.[J]. The Journal of Biological Chemistry, 2000, 275 26: 19728-19734. DOI: 10.1074/jbc.m909960199
[2] ELAINE A LIDINGTON. A role for proteinase-activated receptor 2 and PKC-epsilon in thrombin-mediated induction of decay-accelerating factor on human endothelial cells.[J]. American journal of physiology. Cell physiology, 2005, 289 6: C1437-47. DOI: 10.1152/ajpcell.00502.2004