PAR4 (1-6) amide (mouse) (trifluoroacetate salt)

PAR4 (1-6) amide is a synthetic peptide agonist of proteinase-activated receptor 4 (PAR4) and an amide form of PAR4 (1-6) (Item No. 27131) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of mouse PAR4 and residues 60-65 of the full-length sequence. It induces aggregation of rat platelets with an EC50 value of 40 μM.1 PAR4 (1-6) amide (100 μM) induces smooth muscle relaxation and prostaglandin E2 (PGE2; Item No. 14010) release in isolated mouse tracheal segments, effects that are inhibited by indomethacin (Item No. 70270).2WARNING This product is not for human or veterinary use.

[1] M. HOLLENBERG M S. Proteinase-activated receptor 4 (PAR4): activation and inhibition of rat platelet aggregation by PAR4-derived peptides.[J]. Canadian journal of physiology and pharmacology, 2001, 79 5 1: 439-442. DOI: 10.1139/y01-013
[2] ROMMEL S LAN. Role of PGE2 in protease‐activated receptor‐1, −2 and −4 mediated relaxation in the mouse isolated trachea[J]. British Journal of Pharmacology, 2001, 132 1. DOI: 10.1038/sj.bjp.0703776