C18 3'-sulfo Galactosylceramide-d3 (d18:1/18:0-d3)

C18 3'-sulfo Galactosylceramide-d3 (d18:1/18:0-d3) is intended for use as an internal standard for the quantification of C18 3'-sulfo galactosylceramide (Item No. 24863) by GC- or LC-MS. C18 3'-sulfo Galactosylceramide is a member of the sulfatide class of glycolipids. It is a minor endogenous sphingolipid produced from C18 ceramide (Item No. 19556) and UDP-galactose in the endoplasmic reticulum followed by sulfation in the Golgi apparatus.1 C18 3'-sulfo Galactosylceramide levels are increased in brain tissue isolated from mice with an arylsulfatase A deficiency (ASA-KO), particularly in lipid raft fractions.2,3 Plasma levels of C18 3’-sulfo galactosylceramide positively correlate with disability progression in patients with relapsing-remitting multiple sclerosis using the Expanded Disability Status Scale.4 It is also increased in plasma from patients with metachromatic leukodystrophy (MLD).5 Brain levels of short-chain sulfatides, including C18 3’-sulfo galactosylceramide, decrease with age in mice and humans.2,6 As this product is derived from a natural source, there may be variations in the sphingoid backbone. [Matreya, LLC. Catalog No. 1536]WARNING This product is not for human or veterinary use.

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[2] GIORGIS ISAAC. Sulfatide with short fatty acid dominates in astrocytes and neurons[J]. The FEBS journal, 2006, 273 8: 1782-1790. DOI: 10.1111/j.1742-4658.2006.05195.x
[3] ANA LIS MOYANO . Distribution of C16:0, C18:0, C24:1, and C24:0 sulfatides in central nervous system lipid rafts by quantitative ultra-high-pressure liquid chromatography tandem mass spectrometry[J]. Analytical biochemistry, 2014, 467: Pages 31-39. DOI: 10.1016/j.ab.2014.08.033
[4] ANA L MOYANO. Levels of plasma sulfatides C18 : 0 and C24 : 1 correlate with disease status in relapsing–remitting multiple sclerosis[J]. Journal of Neurochemistry, 2013, 127 5: 600-604. DOI: 10.1111/jnc.12341
[5] JENNIFER T. SAVILLE . Quantification of plasma sulfatides by mass spectrometry: Utility for metachromatic leukodystrophy[J]. Analytica Chimica Acta, 2017, 955: Pages 79-85. DOI: 10.1016/j.aca.2016.12.002
[6] L SVENNERHOLM  S S S. Changes in the fatty acid composition of cerebrosides and sulfatides of human nervous tissue with age.[J]. Journal of Lipid Research, 1968, 9 2: 215-225.