C18 3'-sulfo Galactosylceramide (d18:1/18:0)

C18 3'-sulfo Galactosylceramide is a member of the sulfatide class of glycolipids. It is a minor endogenous sphingolipid produced from C18 ceramide and UDP-galactose in the endoplasmic reticulum followed by sulfation in the Golgi apparatus.¹ C18 3'-sulfo Galactosylceramide levels are increased in brain tissue isolated from mice with an arylsulfatase A deficiency (ASA-KO), particularly in lipid raft fractions.^2,3 Plasma levels of C18 3’-sulfo galactosylceramide positively correlate with disability progression in patients with relapsing-remitting multiple sclerosis using the Expanded Disability Status Scale.⁴ It is also increased in plasma from patients with metachromatic leukodystrophy (MLD).⁵ Brain levels of short-chain sulfatides, including C18 3’-sulfo galactosylceramide, decrease with age in mice and humans.^2,6 As this product is derived from a natural source, there may be variations in the sphingoid backbone.

N-Octadecanoyl-sulfatide is an ester product.

ChEBI: 3-O-Sulfogalactosylceramide (d18:1/18:0) is a glycosphingolipid.

1. Takahashi, T., and Suzuki, T. Role of sulfatide in normal and pathological cells and tissues J. Lipid Res. 53(8),1437-1450(2012).
2. Isaac, G., Pernber, Z., Gieselmann, V., et al. Sulfatide with short fatty acid dominates in astrocytes and neurons FEBS J. 273(8),1782-1790(2006).
3. Moyano, A.L., Li, G., Lopez-Rosas, A., et al. Distribution of C₁₆:0, C₁₈:0, C₂₄:1, and C₂₄:0 sulfatides in central nervous system lipid rafts by quantitative ultra-high-pressure liquid chromatography tandem mass spectrometry Anal. Biochem. 467,31-39(2014).
4. Moyano, A.L., Pituch, K., Li, G., et al. Levels of plasma sulfatides C₁₈ : 0 and C₂₄ : 1 correlate with disease status in relapsing-remitting multiple sclerosis J. Neurochem. 127(5),600-604(2013).
5. Saville, J.T., Smith, N.J.C., Fletcher, J.M., et al. Quantification of plasma sulfatides by mass spectrometry: Utility for metachromatic leukodystrophy Anal. Chim. Acta 955,79-85(2017).
6. Svennerholm, L., and Stllberg-Stenhagen, S. Changes in the fatty acid composition of cerebrosides and sulfatides of human nervous tissue with age J. Lipid Res. 9(2),215-225(1968).