C24:1 3’-sulfo Galactosylceramide is a member of the sulfatide class of glycolipids. It is the predominate sulfatide species in mature myelin, and it accumulates at a higher rate than C24 3’-sulfo galactosylceramide in rat cerebellum from seven to 32 days of age when active myelination occurs.
1 It interacts with C-type lectins and immunoglobulin-like receptors with the highest affinity for LMIR5.
2 It induces production of MCP-1 in basophils but not mast cells and increases the activation of NFAT in a reporter assay
via LMIR5. C24:1 3’-sulfo Galactosylceramide is an immunodominant species in myelin, is bound by CD1d
in vitro, and increases proliferation in isolated mouse splenocytes.
3 It reduces symptoms and increases survival in a mouse model of chronic relapsing-remitting experimental autoimmune encephalomyelitis (EAE) when used at a dose of 20 μg.
4 It also decreases the number of inflammatory lesions and infiltrating mononuclear cells in the lumbar spinal cord of EAE mice.
As this product is derived from a natural source, there may be variations in the sphingoid backbone.
ChEBI: 1-(3-O-sulfo-beta-D-galactosyl)-N-[(15Z)-tetracos-15-enoyl]sphingosine is an N-acyl-beta-D-galactosylsphingosine having a sulfo group at the 3-position on the galactose ring and (15Z)-tetracos-15-enoyl as the N-acyl group. It has a role as an epitope. It is a galactosylceramide sulfate and a N-acyl-beta-D-galactosylsphingosine. It is a conjugate acid of a 1-(3-O-sulfo-beta-D-galactosyl)-N-[(15Z)-tetracos-15-enoyl]sphingosine(1-).
1. Marbois, B.N., Faull, K.F., Fluharty, A.L., et al. Analysis of sulfatide from rat cerebellum and multiple sclerosis white matter by negative ion electrospray mass spectrometry Biochim. Biophys. Acta 1484(1),59-70(2000).
2. Phongsisay, V., Iizasa, E., Hara, H., et al. 3-O-sulfo-β-D-galactose moiety of endogenous sulfoglycolipids is a potential ligand for immunoglobulin-like receptor LMIR5 Mol. Immunol. 63(2),595-599(2015).
3. Zajonc, D.M., Maricic, I., Wu, D., et al. Structural basis for CD1d presentation of a sulfatide derived from myelin and its implications for autoimmunity J. Exp. Med. 202(11),1517-1526(2005).
4. Maricic, I., Halder, R., Bischof, F., et al. Dendritic cells and anergic type I NKT cells play a crucial role in sulfatide-mediated immune regulation in experimental autoimmune encephalomyelitis J. Immunol. 193(3),1035-1046(2014).
