It is an unnatural amino acid ; shown application in the treatment of Parkinson disease, Alzheimer disease, artritis
An unnatural amino acid, that has demonstrated potential in treating Parkinsons disease, Alzheimers disease, and arthritis.
It is an unnatural amino acid ; shown application in the treatment of Parkinson’s disease, Alzheimer’s disease, artritis.
ChEBI: L-m-tyrosine is a hydroxyphenylalanine that is L-phenylalanine with a substituent hydroxy group at position 3. It has a role as a plant metabolite. It is a hydroxyphenylalanine, a L-phenylalanine derivative, a non-proteinogenic L-alpha-amino acid and a member of phenols. It is a tautomer of a L-m-tyrosine zwitterion.
L-Meta-tyrosine is metabolite of L-Phenylalanine generated within the living organism by hydroxyl free radical. It is a marker of oxidative stress. Circulating L-Meta-tyrosine cold be incorporated into protein through the binding to the tRNAPhe. In plants L-Meta-tyrosine (m-Tyr) is also synthesized enzymatically and has been shown to act as a natural herbicide. It inhibits the growth of plants. L-Meta-tyrosine is a potent and selective competitive inhibitor of Enterobacteriaceae (Citrobacter, Proteus, Erwinia) tyrosine phenol-lyase th at exhibits a renoprotective effect in diabetic mice. L-Meta-tyrosine decreases plasma phenyl sulfate and indoxyl sulfate levels and reduces albuminuria in diabetic mice models. Also, L-Meta-tyrosine inhibits bacterial tryptophan indole-lyase. It does not alter composition of microbiota in renal failure mice model.
L-m-tyrosine (150 mg/kg; i.p.; single injection) reduces dopamine, norepinephrine and serotonin levels in the brain to approximately 50% of control values (at 60-90 min after injection) in male Sprague-Dawley rats[3].
