2-乙酰基吩噻嗪
2-乙酰基吩噻嗪 性质
| 熔点 | 180-185 °C (lit.) |
|---|---|
| 沸点 | 455.7±34.0 °C(Predicted) |
| 密度 | 1.249±0.06 g/cm3(Predicted) |
| 储存条件 | Sealed in dry,2-8°C |
| 溶解度 | 可溶于DMSO（轻微）、甲醇（轻微、加热） |
| 酸度系数(pKa) | -2.45±0.20(Predicted) |
| 形态 | 暗黄橙色粉末 |
| 颜色 | 黄色至深橙色 |
| 最大波长(λmax) | 244nm(MeOH)(lit.) |
| CAS 数据库 | 6631-94-3(CAS DataBase Reference) |
2-乙酰基吩噻嗪 用途与合成方法
| Target | Value |
|
NOX1
(HEK293) | 0.25 μM |
|
NOX3
(HEK293) | 3 μM |
|
NOX2
(HEK293) | 5 μM |
|
NOX4
(HEK293) | 5 μM |
|
xanthine oxidase
(HEK293) | 5.5 μM |
Nox1-dependent ROS generation has been shown to play a pivotal role in cell signaling, cell growth, angiogenesis, motility and blood pressure regulation. ML171 strongly blocks ROS generation in HT29 cells (IC 50 =0.129 μM) and only increasing over-expression of Nox1 can overcome the blockage of ROS generation caused by ML171 treatment in HEK293 cell system reconstituted with all the components required Nox1-dependent ROS generation. ML171 efficiently blocks ROS production measured by carboxy-H2-DCFDA staining as well as DPI used as a positive control. When ML171 is tested in HEK293-Nox1 reconstituted cell system, higher potency in blocking Nox1-dependent ROS generation is observed compared with the parental compound.
2-乙酰基吩噻嗪 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-12805 | 2-乙酰基吩噻嗪 | 6631-94-3 | 100mg | 200 |
| 2024-11-08 | HY-12805 | 2-乙酰基吩噻嗪 | 6631-94-3 | 10mM * 1mLin DMSO | 220 |
