1-(2-Pyridyl)piperazine

Product Name1-(2-Pyridyl)piperazine
CAS34803-66-2
MFC9H13N3
MW163.22
EINECS252-220-3
MOL File34803-66-2.mol

Chemical Properties

Melting point	92-94
Boiling point	120-122 °C/2 mmHg (lit.)
Density	1.072 g/mL at 25 °C (lit.)
refractive index	n20/D 1.595(lit.)
Flash point	>230 °F
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Soluble in Chloroform, Methanol.
form	Liquid
pka	8.63±0.10(Predicted)
color	Clear colorless to yellow
Water Solubility	>500 g/L (20 ºC)
Sensitive	Air Sensitive
BRN	140423
InChI	1S/C9H13N3/c1-2-4-11-9(3-1)12-7-5-10-6-8-12/h1-4,10H,5-8H2
InChIKey	GZRKXKUVVPSREJ-UHFFFAOYSA-N
SMILES	C1CN(CCN1)c2ccccn2
CAS DataBase Reference	34803-66-2(CAS DataBase Reference)
NIST Chemistry Reference	1-(2-Pyridyl)piperazine(34803-66-2)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
RIDADR	2735
WGK Germany	3
F	10-34
Hazard Note	Irritant
HazardClass	8
PackingGroup	II
HS Code	29339900
Storage Class	10 - Combustible liquids
Hazard Classifications	Eye Irrit. 2 Skin Irrit. 2 STOT SE 3

MSDS

Provider	Language
1-(2-Pyridyl)piperazine	English
SigmaAldrich	English
ACROS	English
ALFA	English

Usage And Synthesis

Chemical Properties

clear colourless to yellow liquid

Uses

1-(2-Pyridyl)piperazine was used to determine the aliphatic and aromatic isocyanates in air.

Uses

1-(2-Pyridyl)piperazine is a compound that belongs to a class of selective α2-adrenoceptor antagonists. 1-(2-Pyridyl)piperazine shows sympatholytic activity. 1-(2-Pyridyl)piperazine is also a metaboli te of Azaperone (A802200).

General Description

1-(2-Pyridyl)piperazine is a piperazine derivative.

Synthesis

110-85-0

109-04-6

34803-66-2

Step 1: 0.1 g (0.63 mmol) of 2-bromopyridine and 0.065 g (0.75 mmol) of piperazine were placed in a dry 5 mL microwave reactor protected by nitrogen and reacted at 150 °C for 20 min. After completion of the reaction, it was cooled to room temperature. Step 2: The reaction mixture was filtered using diatomaceous earth and the filter cake was washed with ethyl acetate. Step 3: The solvent was removed by distillation under reduced pressure to obtain the crude product. Step 4: Purification of the crude product by silica gel column chromatography with eluent ratio of dichloromethane:methanol=4:1 to obtain 1-(pyridin-2-yl)piperazine in 54% yield.

References

[1] Patent: WO2008/153325, 2008, A1. Location in patent: Page/Page column 43
[2] Patent: WO2006/47415, 2006, A2. Location in patent: Page/Page column 37-38
[3] Journal of the American Chemical Society, 1949, vol. 71, p. 2731,2732
[4] Journal of Organic Chemistry, 1953, vol. 18, p. 1484,1487
[5] Patent: WO2008/62276, 2008, A2. Location in patent: Page/Page column 50

1-(2-Pyridyl)piperazine

Chemical Properties

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Usage And Synthesis

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