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PICROTOXIN

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PICROTOXIN Basic information
PICROTOXIN Chemical Properties
  • Melting point:203 °C(lit.)
  • alpha D16 -29.3° (c = 4 in abs ethanol)
  • Boiling point:571.75°C (rough estimate)
  • Density 1,28 g/cm3
  • refractive index 1.6000 (estimate)
  • storage temp. Store at RT
  • solubility ethanol: 50 mg/mL, clear to slightly hazy
  • form powder
  • color white to light yellow
  • Water Solubility 4.083g/L(room temperature)
  • Merck 14,7415
  • BRN 3894406
  • EPA Substance Registry SystemPicrotoxin (124-87-8)
Safety Information
  • Hazard Codes T+,T,N
  • Risk Statements 28-52/53
  • Safety Statements 28-36/37/39-45-61
  • RIDADR UN 3462 6.1/PG 2
  • WGK Germany 3
  • RTECS TJ9100000
  • 8-10
  • Hazard Note Very Toxic
  • HazardClass 6.1(a)
  • PackingGroup I
  • HS Code 29322985
  • ToxicityLD50 i.p. in mice: 7.2 mg/kg (Setnikar)
MSDS
PICROTOXIN Usage And Synthesis
  • DescriptionPicrotoxin, also known as cocculin, appears as white to light beige crystalline material. It is isolated from Cocculus indicus (Fructus cocculi), fishberries, or Indian berries. Picrotoxin is a colourless, flexible, shining, prismatic crystals, or a micro-crystalline powder. It is odourless, has a very bitter taste, and is permanent in the air. Picrotoxin is soluble in hot water, readily soluble in strong ammonia water, and in aqueous solutions of sodium hydroxide, soluble in dilute acids, and alkalis as well as in glacial acetic acid, sparingly soluble in chloroform and very slightly soluble in cold water and alcohol. Picrotoxin is stable under normal temperatures and pressures and decompose when exposed to light. Picrotoxin is incompatible with strong oxidising agents, strong acids, strong bases, light.
  • Chemical Propertieswhite to off-white powder or crystals
  • Chemical PropertiesPicrotoxin is an odorless crystalline solid with a very bitter taste.
  • General DescriptionA poisonous berry, the dried fruit of Anamirta PICROTOXIN L. Contains several substances including about one percent picrotoxin. Pure picrotoxin occurs as shiny leaflets with an intensely bitter taste or as a microcrystalline powder. Very poisonous!. Used in medicine as a central nervous system stimulant and antidote for barbiturate poisoning. Not currently regarded as a useful therapeutic agent.
  • Reactivity ProfilePICROTOXIN contains picrotoxin, a molecular compound of picrotoxinin and picrotin. May react with strong oxidizing agents and with strong reducing agents.
  • Health HazardHighly toxic and a dose of 20 mg may produce symptoms of severe poisoning. A human lethal dose of 1.5 mg/kg has been reported. It is an alkaloid convulsant poison.
  • Fire HazardWhen heated to decomposition PICROTOXIN emits acrid smoke and fumes. Avoid decomposing heat.
  • Biological ActivityGABA A receptor antagonist; potent CNS stimulant.
  • Safety ProfileA human poison by ingestion. Poison experimentally by most routes. Human systemic effects by ingestion: somnolence, gastrointestinal effects. An alkaloid convulsant poison. When heated to decomposition it emits acrid smoke and irritating fumes.
  • Potential ExposureAn alkaloid poison and convulsant. Used in medicine as a CNS stimulant and antidote for barbiturate poisoning. Reportedly, this material is not currently regarded as a useful therapeutic agent since it is not a selective respiratory stimulant.
  • ShippingUN3462 Toxins, extracted from living sources, solid, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN3172 Toxins, extracted from living sources, (solid or liquid) Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
  • Purification MethodsCrystallise picrotoxin from H2O or Me2CO/H2O. The monoacetate has m 244-245o (*C6H6). [Meyer & Bruger Chem Ber 31 2958 1898, Johns et al. J Chem Soc 4717 1956, Beilstein 19 III/IV 5245.]
  • IncompatibilitiesIncompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.
  • Waste DisposalIt is inappropriate and possibly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, doublebagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.
PICROTOXIN(124-87-8)Related Product Information
PICROTOXINSupplierMore
  • Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
  • Tel:18930552037 821-50328103-801
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  • Email:customerservice@ascentscientific.co.uk
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  • Email:inquiries@lgmpharma.com
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  • Tel:021-50135380
  • Email:shchemsky@sina.com
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