12(S)-HETrE

12(S)-HETrE is produced by 12-lipoxygenase oxidation of dihomo-γ-linolenic acid (DGLA).¹ 12(S)-HETrE is reported to inhibit agonist-mediated platelet activation (IC₅₀ = 40 μM), α granule secretion, integrin αIIbβ3 activation, Rap1 activation, and thrombin-induced clot retraction in vitro.¹

ChEBI: 12(S)-HETrE is a HETrE that is (8Z,10E,14Z)-icosatrienoic acid in which the hydroxy group is located at the 12(S)-posiiton. It has a role as a human xenobiotic metabolite. It is functionally related to an all-cis-icosa-8,11,14-trienoic acid. It is a conjugate acid of a 12(S)-HETrE(1-).

1. Ikei, K.N., Yeung, J., Apopa, P.L., et al. Investigations of human platelet-type 12-lipoxygenase: Role of lipoxygenase products in platelet activation J. Lipid Res. 53(12),2546-2559(2012).