C6 NBD-Sphingosine, beta-D-lactosyl

C6 NBD Lactosylceramide (d18:1/6:0) is a biologically active derivative of lactosylceramides (d18:1/acyl mixture) that is tagged with a fluorescent C-6 nitrobenzoxadiazole (C-6 NBD; ) group.¹ C6 NBD Lactosylceramide (d18:1/6:0) has been used to study the effects of P-glycoprotein inhibition in lactosylceramide metabolism-based therapeutics for the treatment of cancer. As this product is derived from a natural source, there may be variations in the sphingoid backbone.

C6 NBD Lactosylceramide is a derivative of lactosylceramides, and can be used in lactosylceramide synthase assay as a fluorescent acceptor substrate. C6 NBD Lactosylceramide can also be used in cancer research[1][2].

1. Morad, S.A., Davis, T.S., MacDougall, M.R., et al. Role of P-glycoprotein inhibitors in ceramide-based therapeutics for treatment of cancer Biochem. Pharmacol. 130,21-33(2017).