雷尼司他
雷尼司他 性质
| 熔点 | 192-193℃ |
|---|---|
| 沸点 | 702.7±60.0 °C(Predicted) |
| 密度 | 1.83 |
| 储存条件 | Sealed in dry,Store in freezer, under -20°C |
| 酸度系数(pKa) | 10.48±0.20(Predicted) |
| 形态 | 固体 |
| 颜色 | 米白色至粉红色 |
雷尼司他 用途与合成方法
IC50: 11 nM (Rat lens aldose reductase) and 15 nM (Recombinant humanaldose reductase)
Ki: 0.38 nM (Recombinant humanaldose reductase)
Ranirestat concentration-dependently inhibits sorbitol accumulation in rat erythrocytes and sciatic nerves incubated in the high concentration (500 mg/dl) of glucose. The potency of Ranirestat inhibition of sorbitol accumulation is similar between rat erythrocytes and sciatic nerves with IC 50 values of 0.010 μM and 0.041 μM, respectively.
Ranirestat (0.03-1.0 mg/kg; oral administration; once daily; for 3 weeks; male STD-Wistar rats) treatment dose-dependently decreases the elevated sorbitol and fructose levels in the rat sciatic nerves without affecting blood glucose level. Ranirestat also improves the STZ-induced decrease in motor nerve conduction velocity (MNCV) in a dose-dependent manner.
| Animal Model: | Male STD-Wistar rats aged about (12-week-old; 260-290 g) injected with Streptozotocin (STZ) |
| Dosage: | 0.03 mg/kg, 0.1 mg/kg, 0.3 mg/kg, 1 mg/kg |
| Administration: | Oral administration; once daily; for 3 weeks |
| Result: | Dose-dependently decreased the elevated sorbitol and fructose levels in the rat sciatic nerves without affecting blood glucose level. |
雷尼司他 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-15314 | 1 mg | 1181 | ||
| 2024-11-08 | HY-15314 | 雷尼司他 | 147254-64-6 | 5mg | 2600 |
