5-(4-CHLOROPHENYL)-2-FURALDEHYDE

Product Name5-(4-CHLOROPHENYL)-2-FURALDEHYDE
CAS34035-03-5
MFC11H7ClO2
MW206.63
EINECS
MOL File34035-03-5.mol

Chemical Properties

Melting point	128-131 °C (lit.)
Boiling point	350.7±32.0 °C(Predicted)
Density	1.282±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
form	Needles
color	Pale brown
InChI	1S/C11H7ClO2/c12-9-3-1-8(2-4-9)11-6-5-10(7-13)14-11/h1-7H
InChIKey	ROJGJNINTRCMBL-UHFFFAOYSA-N
SMILES	Clc1ccc(cc1)-c2ccc(C=O)o2
CAS DataBase Reference	34035-03-5(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36-37/39
WGK Germany	3
HazardClass	IRRITANT
HS Code	29321900
Storage Class	11 - Combustible Solids
Hazard Classifications	Eye Irrit. 2 Skin Irrit. 2 STOT SE 3

MSDS

Provider	Language
ACROS	English
SigmaAldrich	English

Usage And Synthesis

Chemical Properties

Pale brown needles

Uses

5-(4-Chlorophenyl)furfural was used as one of the aldehydes in the synthesis of uridine-based library.

Uses

5-(4-Chlorophenyl)furfural is a metabolite of Azimilide (A926950, 2 HCl); an oral type III potassium channel blocker agent that blocks both the rapid activating component and the slow activating component of the delayed rectifier potassium current. Both preclinical and clinical studies have demonstrated the efficacy of Azimilide and its safety in the treatment of supraventricular and ventricular tachyarrhythmia. Azimilide is also being studied in a worldwide multicenter trial for prevention of sudden cardiac death in patients after myocardial infarction.

General Description

5-(4-Chlorophenyl)furfural is a furfural derivative.

Synthesis

98-01-1

106-47-8

34035-03-5

The target compounds 5-(4-chlorophenyl)-2-furancarboxaldehyde (1-9) were synthesized using 2-furancarboxaldehyde and 4-chloroaniline as starting materials and the reaction was carried out with reference to the methodology reported in the literature [3,13] and the structures were confirmed by appropriate characterization means.

References

[1] Heterocyclic Communications, 2003, vol. 9, # 6, p. 625 - 628
[2] Synthetic Communications, 2005, vol. 35, # 3, p. 333 - 340
[3] Asian Journal of Chemistry, 2013, vol. 25, # 14, p. 7738 - 7742
[4] Asian Journal of Chemistry, 2017, vol. 29, # 4, p. 735 - 741
[5] Russian Journal of Organic Chemistry, 2009, vol. 45, # 9, p. 1375 - 1381

5-(4-CHLOROPHENYL)-2-FURALDEHYDE

Chemical Properties

Safety Information

MSDS

Usage And Synthesis

Preparation Products And Raw materials

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