硫酸奥西那林
硫酸奥西那林 用途与合成方法
IC50: 68 nM (β2-adrenergic receptor)
Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment enhances β-arrestin2 and its interaction with IκBα in high glucose-induced THP-1 cells and bone marrow macrophages.
Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment leads to downregulation of NF-κB in high glucose-induced THP-1 cells and bone marrow macrophages.
Western Blot Analysis
| Cell Line: | THP-1 cells and bone marrow macrophages |
| Concentration: | 10 μM |
| Incubation Time: | 74 hours |
| Result: | Enhanced β-arrestin2 and its interaction with IκBα. |
RT-PCR
| Cell Line: | THP-1 cells and bone marrow macrophages |
| Concentration: | 10 μM |
| Incubation Time: | 74 hours |
| Result: | Led to downregulation of NF-κB. |
Treatment of Zucker diabetic fatty rats with Metaproterenol for 12 weeks attenuates monocyte activation as well as pro-inflammatory and pro-fibrotic responses in the kidneys and heart. Thus, Metaproterenol might has protective effects against diabetic renal and cardiovascular complications.
安全信息
| 危险品标志 | Xn |
|---|---|
| 危险类别码 | 20 |
| 安全说明 | 36 |
| WGK Germany | 2 |
| RTECS号 | DO2275000 |
| 海关编码 | 2922504500 |
| 毒性 | LD50 in rats (mg/kg): 42 orally (Goldenthal) |
硫酸奥西那林 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-04-30 | HY-B1276 | 硫酸奥西那林 | 5874-97-5 | 50mg | 500 |
| 2024-04-30 | HY-B1276 | 硫酸奥西那林 | 5874-97-5 | 10mM * 1mLin DMSO | 550 |
