Corticosteroid used in the treatment of skin inflammmation and other skin conditions arising for dermatoses.
Clocortolone can be used in the treatment of skin inflammmation and other skin conditions arising for dermatoses.
ChEBI: Clocortolone is 16alpha-Methylpregna-1,4-diene-3,20-dione bearing hydroxy substituents at the 11beta and 21 positions, fluorine at position 6 and chlorine at position 9. A medium potency corticosteroid, it is used as its 21-O-pivalate or caproate ester for the relief of inflammatory and pruritic (itching) skin disorders. It has a role as an anti-inflammatory drug and an antipruritic drug. It is a glucocorticoid, an 11beta-hydroxy steroid, a 21-hydroxy steroid, a 20-oxo steroid, a fluorinated steroid, a 3-oxo-Delta(1),Delta(4)-steroid, a chlorinated steroid and a primary alpha-hydroxy ketone.
6α-Fluoro-16α-methyl-21-hydroxy-1,4,9(11)-pregnatriene-3,20-dione is
suspended in nitroethane at heating. To this suspension 1 N perchloric acid is
added and then t-butyl hypochlorite is added dropwise. The reaction mixture
is agitated at heating, then cooled to room temperature, mixed with
methanol, stirred and then poured with water containing ice. The mixture is
then stirred, thus precipitated product is filtered, washed neutral with water,
dried; The crude product is treated with hot methanol, and recrystallized from
ethanol, thus 9α-chloro-6α-fluoro-11β,21-dihydroxy-16α-methyl-1,4-
pregnadiene-3,20-dione was obtained.
