沙康唑
沙康唑 性质
| 熔点 | 189.5° |
|---|---|
| 沸点 | 812.5±75.0 °C(Predicted) |
| 密度 | 1.37±0.1 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 6.47±0.40(Predicted) |
沙康唑 用途与合成方法
MIC90: 0.19 mg/L
The antifungal activity of Saperconazole is complete at 1 μg/mL for all but one strain of A. niger . Eighty percent of all strains show complete absence of growth at 0.1 μg/mL (85% for A. fumigatus ), and this result persists during 14 days of the test.
All control pigeons infect with A. fumigatus die within 2 to 5 days. They have necrotic foci in the lungs, air sacs, liver, spleen, and kidneys. These organs are highly positive by histology and oncultures. Saperconazole administered at 2.5 mg/kg is not active, but when it is given at 5 or 10 mg/kg, 92 or 100%, respectively, survive and organ cultures are negative. No drug-related side effects are observed in the pigeons.
化合物(Ⅲ)经烷基化后，再水解，得化合物(Ⅳ)。
化合物(Ⅱ)和(Ⅳ)在碱催化下缩合，得沙康唑。
