二苯甲酰基甲烷
二苯甲酰基甲烷 性质
| 熔点 | 77-79 °C(lit.) |
|---|---|
| 沸点 | 219-221 °C18 mm Hg(lit.) |
| 密度 | 0.800 g/cm3 |
| 蒸气压 | 0.01Pa at 20℃ |
| 折射率 | 1.6600 (estimate) |
| 闪点 | 219-221°C/18mm |
| 储存条件 | Store below +30°C. |
| 溶解度 | 可溶于氯仿（轻微）、甲醇（轻微、超声处理） |
| 酸度系数(pKa) | 8.95±0.10(Predicted) |
| 形态 | 晶体 |
| 颜色 | 浅黄色至厚黄色 |
| 水溶解性 | It is Soluble in ether, chloroform, and aqueous sodium hydroxide. Insoluble in water. |
| Merck | 14,3009 |
| BRN | 514910 |
| 稳定性 | 稳定的。与强氧化剂不相容。 |
| InChIKey | NZZIMKJIVMHWJC-UHFFFAOYSA-N |
| LogP | 4.59 at 25℃ |
| CAS 数据库 | 120-46-7(CAS DataBase Reference) |
| NIST化学物质信息 | 1,3-Propanedione, 1,3-diphenyl-(120-46-7) |
| EPA化学物质信息 | 1,3-Propanedione, 1,3-diphenyl- (120-46-7) |
二苯甲酰基甲烷 用途与合成方法
Dibenzoylmethane (10, 20, 30, 40, 50 μM; 6 hours) treatment concentration-dependently increases the mRNA level of HO-1 but has no effect on the mRNA level of Nrf2 in HepG2 cells. Dibenzoylmethane induces HO-1 and Nrf2 protein expression, and the induction diminishes after 12 h.
Dibenzoylmethane (10, 20, 30, 40, 50 μM; 2 hours) concentration-dependently increases the phosphorylated protein levels of Erk1/2, p38MAPK, JNK, AMPK, and Akt in HepG2 cells.
Dibenzoylmethane does not show significant cytotoxicity.
Dibenzoylmethane (200, 500 mg/kg/day; ip; for three consecutive days) pretreatment significantly reduces both the area and the severity of necrosis, as well as the leukocyte infiltration, at a dose of 200 mg/kg in wild-type and Nrf2 knockout mice.
Dibenzoylmethane protectes against CCl4-induced (1:49,v/v, 10 ml/kg) liver damage in wild-type mice.
安全信息
| 危险品标志 | Xi |
|---|---|
| 危险类别码 | 36/37/38 |
| 安全说明 | 22-24/25 |
| WGK Germany | 3 |
| RTECS号 | TZ1930000 |
| Hazard Note | Irritant |
| TSCA | Yes |
| 海关编码 | 29143900 |
| 毒性 | rat,LD,oral,> 500mg/kg (500mg/kg),National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. Vol. 5, Pg. 28, 1953. |
MSDS信息
二苯甲酰基甲烷 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | A13450 | 1,3-二苯基-1,3-丙二酮, 98+% | 120-46-7 | 25g | 409 |
| 2024-11-08 | A13450 | 1,3-二苯基-1,3-丙二酮, 98+% | 120-46-7 | 100g | 1244 |
