二苯甲酰基甲烷

生物活性体外研究体内研究二苯甲酰基甲烷试剂级价格

二苯甲酰基甲烷

CAS号:120-46-7
英文名:Dibenzoylmethane
中文名:二苯甲酰基甲烷
CBNumber:CB7175433
分子式:C15H12O2
分子量:224.25
MOL File:120-46-7.mol

二苯甲酰基甲烷化学性质

熔点 :77-79 °C(lit.)
沸点 :219-221 °C18 mm Hg(lit.)
密度 :0.800 g/cm3
蒸气压 :0.01Pa at 20℃
折射率 :1.6600 (estimate)
闪点 :219-221°C/18mm
储存条件 :Store below +30°C.
溶解度 :Chloroform (Slightly), Methanol (Slightly, Sonicated)
酸度系数(pKa) :8.95±0.10(Predicted)
形态 :Crystals
颜色 :Light yellow to yellow
水溶解性 :It is Soluble in ether, chloroform, and aqueous sodium hydroxide. Insoluble in water.
Merck :14,3009
BRN :514910
稳定性 :Stable. Incompatible with strong oxidizing agents.
InChIKey :NZZIMKJIVMHWJC-UHFFFAOYSA-N
LogP :4.59 at 25℃
CAS 数据库 :120-46-7(CAS DataBase Reference)
NIST化学物质信息 :1,3-Propanedione, 1,3-diphenyl-(120-46-7)
EPA化学物质信息 :1,3-Propanedione, 1,3-diphenyl- (120-46-7)

安全信息

危险品标志 :Xi
危险类别码 :36/37/38
安全说明 :22-24/25
WGK Germany :3
RTECS号 :TZ1930000
Hazard Note :Irritant
TSCA :Yes
海关编码 :29143900
毒性 :rat,LD,oral,> 500mg/kg (500mg/kg),National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. Vol. 5, Pg. 28, 1953.

二苯甲酰基甲烷 MSDS

Dibenzoylmethane

二苯甲酰基甲烷性质、用途与生产工艺

生物活性 Dibenzoylmethane 是甘草中的次要成分，可激活 Nrf2 并预防各种癌症和氧化损伤。Dibenzoylmethane 是姜黄素的类似物，会引起 Keap1 解离和 Nrf2 的核易位。
体外研究

Dibenzoylmethane (10, 20, 30, 40, 50 μM; 6 hours) treatment concentration-dependently increases the mRNA level of HO-1 but has no effect on the mRNA level of Nrf2 in HepG2 cells. Dibenzoylmethane induces HO-1 and Nrf2 protein expression, and the induction diminishes after 12 h.
Dibenzoylmethane (10, 20, 30, 40, 50 μM; 2 hours) concentration-dependently increases the phosphorylated protein levels of Erk1/2, p38MAPK, JNK, AMPK, and Akt in HepG2 cells. Dibenzoylmethane does not show significant cytotoxicity.
体内研究

Dibenzoylmethane (200, 500 mg/kg/day; ip; for three consecutive days) pretreatment significantly reduces both the area and the severity of necrosis, as well as the leukocyte infiltration, at a dose of 200 mg/kg in wild-type and Nrf2 knockout mice.
Dibenzoylmethane protectes against CCl4-induced (1:49,v/v, 10 ml/kg) liver damage in wild-type mice.
化学性质无色斜方形片状结晶。熔点81℃，沸点219℃（2.4kPa）。易溶于氯醇、氯仿，能溶于氢氧化钠溶液，不溶于碳酸钠溶液，极微溶于水。
用途分析试剂，检定二硫化碳和铊，重量测定铀，光度测定U+4，萃取银、铝、钡、铍、钙、镉、钴、铜、铁、镓、汞、锢、镧、镁、锰、镍、铅、钯、钪、钍、钛、锌、锆等。
用途作为钙/锌羟酸盐稳定体系的共稳定剂，用来制造PVC矿泉水瓶
生产方法由苄叉乙酰基苯为原料，经溴化、水解得到。