Momordin Ic (12.5, 25, 50 mg/kg, p.o.) accelerates gastrointestinal transport and inhibits gastric emptying in mice by stimulating the synthesis of serotonin (5-HT)[4].
Momordin Ic (10 mg/kg, p.o.) can inhibit ethanol induced gastric mucosal lesions in rats[5].
Momordin Ic (30 mg/kg, once a day for 14 days, p.o.) can reduce CCl4-induced hepatotoxicity in rats[6].
| Animal Model: | Male ddY mice[4]. |
| Dosage: | 12.5, 25, 50 mg/kg |
| Administration: | Oral gavage (p.o.) |
| Result: | Accelerated gastrointestinal transit in fasted mice. |
| Animal Model: | Male Sprague-Dawley rat[5]. |
| Dosage: | 10 mg/kg |
| Administration: | Oral gavage (p.o.) |
| Result: | Reduced the length of the lesions. |
| Animal Model: | Male Sprague–Dawley rat[6]. |
| Dosage: | 30 mg/kg |
| Administration: | Oral gavage (p.o.), once a day for 14 days |
| Result: | Reduced serum transaminase, lactic dehydrogenase, and γ-glutamyltransferase levels in the CCl4-treated rats. |
