Dynorphin A (intracerebroventricular injection, 1 μg of 2 μL, a single dose) inhibits vasopressin (VP) release in 24 h water-deprived male rats[5].
Dynorphin A (intracerebroventricular injection, 500 pmol/5 μL per day for 4 d) alleviates stress-induced behavioral impairments in ddY mice accompanied by regulation of the 5-HTergic system in the brain[6].
| Animal Model: | 24 h water-deprived male rats[5] |
| Dosage: | 1 μg of 2 μL |
| Administration: | Intracerebroventricular injection |
| Result: | Inhibited vasopressin (VP) release 30 min upon injection. |
| Animal Model: | Male ddY mice[6] |
| Dosage: | 15, 150, 1500 pmol/5 μL per day for 4 days |
| Administration: | Intracerebroventricular injection |
| Result: | Attenuated the repeated stress-induced escape failures from the shock. |