Cephaeline (2 mg/kg, i.p.,daily for 3 days) suppresses ZIKV load and decreases the NS1 protein and ZIKV RNA in serum of ZIKV infected Ifnar1/ mice[2].
Cephaeline (5 mg/kg, i.p.,daily for 7 days) effectively suppressed EBOV infection in EBOV mouse models[3].
Cephaeline (5, 10 mg/kg, i.p., a single dose for 12 days) plays an anti-lung cancer role by inducing ferroptosis in tumor xenograft mouse model[4].
| Animal Model: | Ifnar1/ mice infected with ZIKV (8-9 week old, male and female)[2] |
| Dosage: | 2 mg/kg |
| Administration: | i.p.,daily for 3 days |
| Result: | Significantly lowered the serum viral load of ZIKV infected Ifnar1/ mice and decreased the NS1 protein and ZIKV RNA in serum and liver of mice, respectively. |
| Animal Model: | EBOV mouse model[3] |
| Dosage: | 5 mg/kg |
| Administration: | i.p., daily for 7 days |
| Result: | Achieved 67% survival in EBOV infection to death in EBOV mouse model. |
| Animal Model: | Tumor xenograft mouse model injected with the lung cancer H460 cell line[4] |
| Dosage: | 5, 10 mg/kg |
| Administration: | i.p., a single dose for 12 days |
| Result: | Showed significant antitumour effects in tumor xenograft mouse model. |
