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EMETINE

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EMETINE Basic information
EMETINE Chemical Properties
  • Melting point:89-96°C
  • alpha D20 -50° (c = 2 in CHCl3)
  • Boiling point:578.63°C (rough estimate)
  • Density 1.1174 (rough estimate)
  • refractive index 1.5800 (estimate)
  • storage temp. -20?C Freezer
  • pka5.77, 6.64(at 25℃)
  • Water Solubility 961.3mg/L(15 ºC)
Safety Information
  • RIDADR 1544
  • HazardClass 6.1(b)
  • PackingGroup III
  • ToxicityLD50 i.p. in rats: 12.1 mg/kg (Radomski)
EMETINE Usage And Synthesis
  • Chemical PropertiesBrown Solid
  • UsesEmetine is the principal alkaloid of ipecac, the ground roots of Uragoga ipecacuanha.
  • UsesEmetine occurs in the ground roots ofipecac (Uragoga ipecacuanha, Cephaelisipecacuanha, Uragoga acuminata, and Rubiaceae). Ipecacs are of two varieties, Brazilianand Cartagena. The former contains about1.2–1.5% emetine, and the latter constitutesabout 1.1–1.4% emetine. It is used as anemetic to induce vomiting for the treatmentof poisoning. It is also used as an antiamebic.
  • IndicationsChlorprothixene (Taractan) has been reported twice to be effective in the treatment of PHN. For severe pain, an initial 50 to 100 mg IM injection has been advocated. Otherwise, the dosage is 25 to 50 mg PO q6h. The recommended duration of therapy is 4 to 10 days. Higher doses are unwarranted and frequently result in side effects.
  • DefinitionChEBI: A pyridoisoquinoline comprising emetam having methoxy substituents at the 6'-, 7'-, 10- and 11-positions.
  • brand nameAsmorex;Broncho-tetracycline;Dicton-retard;Emedrin;Emetocamphrol;Hemometina;Optairosol;Pectinfant.
  • World Health Organization (WHO)Emetine, an alkaloid obtained from ipecacuanha, was first used rationally as an amoebocide in 1912. It was subsequently widely used and was included in earlier editions of the WHO Model List of Essential Drugs but has now been replaced by the less cardiotoxic synthetic derivative dehydroemetine. Although it is valuable in the treatment of systemic amoebic hepatitis it has now been largely superseded by considerably less toxic drugs, and in particular by metronidazole.
  • HazardToxic by ingestion.
  • Health HazardThe toxicity of cephaeline is lower than thatof emetine. The toxic effects are cumulative. Ingestion of high doses may producehypotension, muscle weakness, and gastroin testinal problems, including nausea, vomit ing, and diarrhea.
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