White or almost white, crystalline powder.
Antihistaminic;H1 antogonist
ChEBI: A hydrochloride comprising equimolar amounts of ophenadrine and hydrogen chloride.
Odorless white or almost white crystalline powder. pH (aqueous solution) about 5.5. Bitter numbing taste.
May be sensitive to prolonged exposure to light and air. Water soluble.
ORPHENADRINE HYDROCHLORIDE is incompatible with strong oxidizers.
Flash point data for ORPHENADRINE HYDROCHLORIDE are not available; however, ORPHENADRINE HYDROCHLORIDE is probably combustible.
Muscarinic receptor antagonist; H1 histamine receptor antagonist; muscle relaxant. Orphenadrine has also been reported to inhibit the noradrenergic transporter and to block the NMDA receptor ion channel.
Anti-muscarinic:
Parkinsonism
Drug induced extra-pyramidal symptoms
Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Human systemic effects: mydriasis @updlaryd ilation), hallucinations, distorted perceptions, pulse rate increase, intracranial pressure increase. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and HCl
Orphenadrine is almost completely metabolised to at least
8 metabolites in the liver.
It is mainly excreted in the urine as metabolites and small
amounts of unchanged drug
