Cholestane-3,5-diol, 6-[[2-(1H-imidazol-5-yl)ethyl]amino]-, (3β,5α,6β)-

Dendrogenin A (DDA) is a ligand for liver X receptor (LXR), that induces the expression of sodium/iodine symporter, and increases iodine uptake. Dendrogenin A induces cell differentiation of MCF-7, and reactivates the function of lactating cells. Dendrogenin A induces the expressions of the TSH receptor, thyroid peroxidase, and thyroglobulin, and affects thyroid hormone generation. Dendrogenin A exhibits cytotoxicity in cancer cell B-CPAP and 8505c with IC50 of 4.1 and 6.2 μM. Dendrogenin A arrests the cell cycle at G0/G1 phase[1].

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