Cholestane-3,5-diol, 6-[[2-(1H-imidazol-5-yl)ethyl]amino]-, (3β,5α,6β)-

Uses

Dendrogenin A (DDA) is a ligand for liver X receptor (LXR), that induces the expression of sodium/iodine symporter, and increases iodine uptake. Dendrogenin A induces cell differentiation of MCF-7, and reactivates the function of lactating cells. Dendrogenin A induces the expressions of the TSH receptor, thyroid peroxidase, and thyroglobulin, and affects thyroid hormone generation. Dendrogenin A exhibits cytotoxicity in cancer cell B-CPAP and 8505c with IC50 of 4.1 and 6.2 μM. Dendrogenin A arrests the cell cycle at G0/G1 phase[1].

References

[1] Bauriaud-Mallet M, et al., The cholesterol-derived metabolite dendrogenin A functionally reprograms breast adenocarcinoma and undifferentiated thyroid cancer cells. J Steroid Biochem Mol Biol. 2019 Sep;192:105390. DOI:10.1016/j.jsbmb.2019.105390
[2] MARC POIROT  Sandrine S P. The tumor-suppressor cholesterol metabolite, dendrogenin A, is a new class of LXR modulator activating lethal autophagy in cancers[J]. Biochemical pharmacology, 2018, 153: Pages 75-81. DOI: 10.1016/j.bcp.2018.01.046
[3] PHILIPPE DE MEDINA. Dendrogenin A arises from cholesterol and histamine metabolism and shows cell differentiation and anti-tumour properties.[J]. Nature Communications, 2013: 1840. DOI: 10.1038/ncomms2835
[4] RÉGIS SOULÈS . A fast UPLC–HILIC method for an accurate quantification of dendrogenin A in human tissues[J]. Journal of Steroid Biochemistry and Molecular Biology, 2019, 194: Article 105447. DOI: 10.1016/j.jsbmb.2019.105447
[5] GREGORY SEGALA. Dendrogenin A drives LXR to trigger lethal autophagy in cancers.[J]. Nature Communications, 2017: 1903. DOI: 10.1038/s41467-017-01948-9