Uses
DMHCA has been used as LXR activator to tre at retinal endothelial cells in order to activate the sirtuin 1- liver X receptors (SIRT1-LXR) pathway.', 'It may be used as 3β-hydroxysterol-Δ24-reductase (DHCR24) inhibitor.
Biological Activity
N,N-dimethyl-3β-hydroxycholenamide (DHMCA) halts cholesterol biosynthesis by inhibiting 3β-hydroxysterol-Δ24-reductase (DHCR24) enzyme. It may serve as a therapeutic agent for treating atherosclerosis, age-related macular degeneration and diabetic retinopathy.', 'DMHCA (N,N-dimethyl-3β-hydroxycholenamide) is a synthetic oxysterol and is an agonist for liver X receptors (LXR). It promotes cholesterol transport, expression of adenosine triphosphate (ATP) binding cassette transporters. DMHCA suppresses the proinflammatory cytokines stimulation, induced by oxysterol.
