AMG 333 (0.6-3 mg/kg, p.o., single dose) dose-dependently inhibits wet-dog shake behavior in the Icilin (HY-11062)-induced wet-dog shake SpragueDawley rat model, demonstrating that AMG 333 effectively blocks the TRPM8 target[1].
AMG 333 (1-3 mg/kg, p.o., single dose) dose-dependently blocks blood pressure elevation in the cold stimulation-induced blood pressure elevation SpragueDawley rat model, indicating that AMG 333 effectively acts on the TRPM8 target[1].
| Animal Model: | Icilin (HY-11062)-induced wet-dog shake (WDS) behavior in SpragueDawley rat model[1] |
| Dosage: | 0.6, 1, 3 mg/kg |
| Administration: | Oral gavage (p.o.), single dose |
| Result: | Demonstrated significant dose-dependent inhibition;
3 mg/kg fully inhibited WDS. |
| Animal Model: | Cold stimulation-induced blood pressure elevation SpragueDawley rat model[1] |
| Dosage: | 1, 3 mg/kg |
| Administration: | Oral gavage (p.o.), single dose |
| Result: | Showed significant inhibition of cold-induced blood pressure elevation at 1 mg/kg and 3 mg/kg;
3 mg/kg fully blocked cold-pressor response. |
