Maresin 2-d5

Maresin 2-d5 (MaR2-d5) contains 5 deuterium atoms at the 21, 21, 22, 22, and 22 positions. It is intended for use as an internal standard for the quantification of MaR2 (Item No. 16369) by GC- or LC-MS. MaR2 is a 13R,14S-dihydroxy DHA formed by recombinant human macrophage 12-lipoxygenase and soluble epoxide hydrolase co-incubated with DHA.1 At 1 ng/mouse, MaR2 was shown to reduce neutrophil infiltration by 40% in a mouse model of peritonitis, and at 10 pM, MaR2 can enhance human macrophage phagocytosis of zymosan A by 90%.1WARNING This product is not for human or veterinary use.

[1] BIN DENG. Maresin biosynthesis and identification of maresin 2, a new anti-inflammatory and pro-resolving mediator from human macrophages.[J]. PLoS ONE, 2014: e102362. DOI: 10.1371/journal.pone.0102362
[2] SATORU SUGIMOTO. Brown adipose tissue-derived MaR2 contributes to cold-induced resolution of inflammation[J]. Nature metabolism, 2022, 4 6: 775-790. DOI: 10.1038/s42255-022-00590-0