Maresin 1-d5

Maresin 1-d5 is intended for use as an internal standard for the quantification of maresin 1 (Item No. 10878) by GC- or LC-MS. Maresin 1 is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids.1 It is produced from docosahexaenoic acid (DHA; Item Nos. 90310 | 17950) in human peripheral blood mononuclear cells (PBMCs). Maresin 1 (100 nM) reduces TNF-α-induced increases in reactive oxygen species (ROS) in primary human vascular smooth muscle and endothelial cells.2 It decreases disease severity, neutrophil infiltration, and intestinal crypt damage in a mouse model of colitis induced by dextran sulfate (DSS; Item No. 23250) when administered at doses of 0.3 and 1 µg/animal.3 Maresin 1 (0.1, 1, and 10 ng/animal) inhibits increases in inflammatory exudate polymorphonuclear (PMN) neutrophil infiltration in a mouse model of peritonitis induced by zymosan A (Item No. 21175).1 It has been found in the synovial fluid of rheumatoid arthritis patients.4WARNING This product is not for human or veterinary use.

[1] CHARLES N SERHAN. Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain.[J]. FASEB Journal, 2012, 26 4: 1755-1765. DOI: 10.1096/fj.11-201442
[2] ANURAN CHATTERJEE. The pro-resolving lipid mediator maresin 1 (MaR1) attenuates inflammatory signaling pathways in vascular smooth muscle and endothelial cells.[J]. PLoS ONE, 2014: e113480. DOI: 10.1371/journal.pone.0113480
[3] RODRIGO MARCON. Maresin 1, a proresolving lipid mediator derived from omega-3 polyunsaturated fatty acids, exerts protective actions in murine models of colitis.[J]. Journal of immunology, 2013, 191 8: 4288-4298. DOI: 10.4049/jimmunol.1202743
[4] MARTIN GIERA . Lipid and lipid mediator profiling of human synovial fluid in rheumatoid arthritis patients by means of LC–MS/MS[J]. Biochimica et biophysica acta. Molecular and cell biology of lipids, 2012, 1821 11: Pages 1415-1424. DOI: 10.1016/j.bbalip.2012.07.011
[5] SATORU SUGIMOTO. Brown adipose tissue-derived MaR2 contributes to cold-induced resolution of inflammation[J]. Nature metabolism, 2022, 4 6: 775-790. DOI: 10.1038/s42255-022-00590-0
[6] DAVID MERIWETHER. Apolipoprotein A-I mimetics mitigate intestinal inflammation in COX2-dependent inflammatory bowel disease model.[J]. Journal of Clinical Investigation, 2019, 129 9: 3670-3685. DOI: 10.1172/jci123700