Ro 19-4603 is a novel benzodiazepine inverse agonist.
ChEBI: Ro 19-4603 is an organonitrogen heterocyclic compound, an organosulfur heterocyclic compound and a tert-butyl ester.
Benzodiazepine inverse agonist. Binds with high affinity to both diazepam-sensitive (DS) and diazepam-insensitive (DI) GABA A receptors (K i values are ~ 0.2 and ~ 2.6 nM for DS and DI receptors respectively). Antagonizes effects of ethanol on locomotor behavior and suppresses ethanol intake in alcohol-preferring rats.
Ro19-4603 (0-0.3 mg/kg, i.p.) markedly reduces EtOH intake at the 8-h interval in alcohol-preferring rats[1].
| Animal Model: | Alcohol-Preferring rats[1] |
| Dosage: | 0.075, 0.150, and 0.30 mg/kg. |
| Administration: | i.p. |
| Result: | Reduced EtOH intake at the 8-h interval, but no apparent effect at the 24-h interval. |
![5,6-Dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a]thieno[2,3-f][1,4]diazepine-3-carboxylic acid 1,1-dimethylethyl ester Structure](/CAS/GIF/99632-94-7.gif)
