罗丹明
罗丹明 性质
熔点 | >300 °C(lit.) |
---|---|
密度 | 1.2504 (rough estimate) |
折射率 | 1.6470 (estimate) |
储存条件 | Keep in dark place,Inert atmosphere,Room temperature |
溶解度 | 可溶于乙醇 |
形态 | 结晶粉末 |
颜色 | 白色至浅黄色至浅橙色 |
最大波长(λmax) | 499nm (MeOH); 496nm (H2O) |
BRN | 4631860 |
稳定性 | 有吸湿性、光敏性 |
主要应用 | Color filters; liquid crystal displays; dye lasers;electroluminescent displays;inks;light-emitting diode (LED);papermaking process; recording materials; solar cells; silica thin films;sol–gel titania films;waveguides |
生物领域应用 | Detecting risk of Alzheimer’s disease and stroke;evaluating/testing sperm quality; identifying bacteria; as a substrate for measuring aromatase activity, azoreductase activity,phospholipase activity, proteases activity (caspase activity, cathepsin C activity, elastase activity proteinase activity);implantable drug-delivery devices |
CAS 数据库 | 13558-31-1(CAS DataBase Reference) |
EPA化学物质信息 | Xanthylium, 3,6-diamino-9-(2-carboxyphenyl)-, chloride (13558-31-1) |
罗丹明 用途与合成方法
Rhodamine 110 accumulates in mitochondria in a cationic form, which alters the pH in this cellular compartment. Rhodamine 110 accumulates in human lymphoblastoid cells and Friend leukemia cells. No cytotoxicity to human lymphoblastoid cells is observed below 10 μM, but Rhodamine 110 causes Friend leukemia cells to die at a concentrations above 100 μM.
Rhodamine 110 is less toxic than the parent molecule based on the intravenous LD 50 acute toxicity values of 89.5 mg/kg and 140.0 mg/kg for Rhodamine B and Rhodamine 110, respectively. Both molecules induce liver and kidney enlargement after ingestion, and male rats show more significant increases than female rats after Rhodamine 110 exposure. In addition, testis weight increased in male rats dosed with Rhodamine 110. The pharmacokinetics of Rhodamine 110 are assessed following oral administration at two dosages (3 and 10 mg/kg) and intravenous administration at one dosage (3 mg/kg). Pharmacokinetic parameters are calculated using an extravascular input and IV-bolus input, noncompartmental model analysis conducted with WinNonlin Standard Edition. The pharmacokinetic parameters of Rhodamine 110 indicates that the maximum plasma concentrations (C max ) of the two oral dosages are 283.4 and 657.0 ng/mL, which are reached at 140 and 210 min, respectively. This indicates that Rhodamine 110 absorption is not rapid after ingestion, as it took over 2 h to be absorbed from the intestines into the blood. The areas under the concentration–time curves (AUCs) for the two dosages are 138.1±20.3 and 444.0±170.8 h ng/mL. The pharmacokinetic data demonstrate that the AUC is proportional to the administered oral dose of Rhodamine 110 (3 mg/kg and 10 mg/kg). Furthermore, the clearance (Cl) of the two orally administered doses is 7.94 and 8.61 mL/min/kg, respectively.
罗丹明 价格(试剂级)
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024-11-11 | XW135583112 | 罗丹明110 | 13558-31-1 | 500MG | 1428 |
2024-11-11 | XW135583111 | 罗丹明110 | 13558-31-1 | 100MG | 428 |