p-(p-Dimethylaminophenylazo)benzoic acid sodium salt

orange crystalline powder

Dabcyl acid sodium (DABCYL sodium) is a nonfluorescent chromophore and a quencher. Dabcyl acid sodium can be used as molecular beacon nucleic acid probes to recognize and report the presence of specific nucleic acids in homogeneous solutions[1][2].

It has been precipitated from aqueous solution as the free acid which was recrystallised from 95% EtOH, then reconverted to the sodium salt. [Beilstein 16 H 329.]

[1] Tyagi S, et al. Molecular beacons: probes that fluoresce upon hybridization. Nat Biotechnol. 1996 Mar;14(3):303-8. DOI:10.1038/nbt0396-303
[2] Conlon P, et al. Pyrene excimer signaling molecular beacons for probing nucleic acids. J Am Chem Soc. 2008 Jan 9;130(1):336-42. DOI:10.1021/ja076411y