4-Bromo-2-chlorophenol

95-57-8

3964-56-5

2040-88-2

4526-56-1

GENERAL METHODS: REACTION CONDITIONS: Thiourea (5.1 mol%, 2 mg, 0.026 mmol) was added to an acetonitrile solution (10 mL) containing N-bromosuccinimide (NBS, 1.15 eq, 104.4 mg, 0.587 mmol). 2-Chlorophenol (56.3 mg, 0.51 mmol) was immediately added to the resulting stirred solution and stirred for 10 min at room temperature. The reaction was quenched by the addition of 10% Na2S2O3 aqueous solution (10 mL) and extracted with ethyl acetate (70 mL). The organic phase was washed sequentially with 10% Na2S2O3 aqueous solution (2 × 10 mL), deionized water (3 × 15 mL), and saturated saline (2 × 10 mL). The organic phase was dried with anhydrous Na2SO4 and concentrated under reduced pressure to remove the solvent. The products were separated and purified by centrifugal thin layer chromatography (silica gel 60GF254 plate, 2 mm thickness, unfolding agent 5% dichloromethane/hexane). The products obtained are known compounds and their structures were confirmed by GC-MS, IR, 1H NMR and 13C NMR, and the spectral data were in agreement with those reported in the literature.