RNA Polymerase III Inhibitor
RNA Polymerase III Inhibitor 性质
| 储存条件 | = -70C |
|---|---|
| 溶解度 | 溶于 DMSO（最高 35 mg/ml）或乙醇（升温最高 5 mg/ml） |
| 形态 | 类白色固体 |
| 颜色 | 米白色 |
| 稳定性 | 可在-20°C下的DMSO或乙醇溶液保存长达2个月。 |
RNA Polymerase III Inhibitor 用途与合成方法
Combination of SAHA and ML-60218 produces enhanced suppression of proliferation in human pancreatic adenocarcinoma by impairing cell cycle progression and inducing apoptosis. ML-60218 reverses SAHA-stimulated tRNA expression in PANC-1 and BxPC-3 cells. ML-60218 enhances the ability of HDAC inhibitors to induce apoptosis and cell cycle arrest.
In in vitro transcription assays with purified double-layered particles (DLPs), ML-60218 shows dose-dependent inhibitory activity, indicating the viral nature of its target. ML-60218 is found to interfere with the formation of higher-order structures of VP6, the protein forming the DLP outer layer, without compromising its ability to trimerize. Electron microscopy of ML-60218-treated DLPs shows dose-dependent structural damage. ML-60218-mediated (10 μM ) viroplasm disruption causes NSP5 dephosphorylation.
